Best of Enemies is a behind-the-scenes account of the explosive televised debates between the liberal Gore Vidal and the conservative William F. Buckley Jr., during the 1968 Democratic and Republican national conventions. Live and unscripted, they kept viewers riveted with their rancorous disagreements about politics, God, and sex. Ratings for ABC News sky-rocketed; and a new era in public discourse was born.

Academy Award-winning Morgan Neville (Twenty Feet From Stardom) and Grammy-Award winning Robert Gordon deftly chronicle the series of TV clashes between Vidal and Buckley that would set the bench-mark for future political reporting and ushered in the dawn of the TV political pundit. In addition to footage from the televised debates and interviews with friends and colleagues, the bitterness and animosity between the two political rivals is illustrated by readings from their memoirs and letters, with John Lithgow voicing Gore Vidal and Kelsey Grammer taking on William F. Buckley Jr.